Ongoing research being developed at the IIoT competence center, fortiss, is focused on networking and computing architectures as basis for an efficient deployment and orchestration of heterogeneous and de-centralized services and resources. Specific aspects concern interoperability aspects, in particular when facing large-scale critical environments with heterogeneous components, such as in Industrial IoT environments. Specific topics: Edge/Fog/cloud computing; semantic behavior to support real-time system adaptation; in-network computing architectures.